Cardinals vs. Chiefs odds, picks, line, how to watch, live stream: Model reveals 2022 Week 1 NFL predictions

AFC visits NFC in Week 1 of the 2022 NFL season as Patrick Mahomes and the Kansas City Chiefs travel to Grand Canyon State to fight Kyler Murray and the Arizona Cardinals on Sunday on Paramount+. The Chiefs are 4-0 in Week 1 since Mahomes took over at center but are entering uncharted territory with star wide receiver Tyreek Hill no longer on the team. Meanwhile, the Cardinals are trying to reflect a disappointing 2021 season and a dramatic offseason in the rearview mirror. You can stream the game on Paramount+ in select markets.

Kick-off from University of Phoenix Stadium in Glendale, Arizona is scheduled for 4:25 p.m. ET on Sunday. The Chiefs are six-point favorites in Caesars Sportsbook’s latest Cardinals vs. Chiefs odds, and the over/under for total points is 53.5. In select markets, Sunday’s matchup can be seen live on CBS and streamed live on Paramount+ with the must-have Premium plan.

Paramount+ now has membership tiers so you can watch your local NFL on CBS matches and more. The premium plan costs $9.99 per month and lets you watch your local CBS live stream, including many sports like SEC on CBS, NFL on CBS, and the PGA Tour, ad-free, on-demand, and with the ability to add episodes to the Download Offline Viewer. Both plans come with a free freshman week and include the NFL on CBS, so sign up here now.

How to watch Chiefs vs Cardinals

  • Chiefs vs. Cardinals Date: Sunday, September 11th
  • Chiefs vs. Cardinals time: 4:25 p.m. ET
  • Chiefs vs Cardinals TV: CBS
  • Chiefs vs. Cardinals Streaming: Paramount+

Week 1 NFL picks for Cardinals vs. Chiefs

Before you tune into Sunday’s Cardinals vs. Chiefs game, you need to look at SportsLine’s advanced computer model NFL picks. The model, which simulates every NFL game 10,000 times, has won over $7,500 for $100 players with top-tier NFL picks since its inception. The model kicks off the 2022 NFL season with an incredible 138-97 run of top-flight NFL picks, stretching back to the 2017 season. Amazingly, it hasn’t missed out on a top-flight pick since week 15 of last season.

The model has also ranked in the top 10 on NFLPickWatch for four of the last six years in direct NFL picks, beating more than 94% of CBS Sports football pick ’em players four times in that span. Whoever followed it is way up.

For Cardinals vs. Chiefs, the model selects Arizona to cover the spread. The Chiefs have 17 overall wins, not covering the span from 2018, and the Cardinals did very well in the season opener under Kliff Kingsbury. While the model predicts that the favorite Chiefs will still narrowly win, it selects the home team for cover.

A lot of attention will be on offense, between how Patrick Mahomes drives the offense down the field without Tyreek Hill as one of his primary targets, and how Arizona balances an injured roster. Cardinals receiver Rondale Moore will be a game decider after injuring his hamstring during practice, further exhausting a receiver corps short of Antoine Wesley (hip/groin) and DeAndre Hopkins (suspension). However, Arizona got some good news on Friday when tight end Zach Ertz returned to practice and ran stretches.

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How to Watch the NFL Live on CBS

Now that you know what to choose, you can watch your live local NFL games on CBS on Paramount+ on any device. Visit Paramount+ now to stream your local CBS sporting events live, including the NFL, SEC on CBS and more.

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