NFL odds Week 1: How to bet Chiefs-Cardinals

A strong non-conference matchup to open the 2022 NFL season.

The Kansas City Chiefs head to the desert for a week one showdown against the Arizona Cardinals at 4:25 p.m. ET Sunday at State Farm Stadium.

The Kansas City Chiefs, winners of six straight AFC West titles, begin life without jack-of-all-trades superstar wide receiver Tyreek Hill, who was traded to Miami during the offseason. But the good news is Patrick Mahomes is still in town, and with him, the Chiefs are expected to do great things — they currently have the third-lowest odds of winning the Super Bowl on FOX Bet.

The Arizona Cardinals started 2021 on fire, taking a 10-2 lead after the first 12 games of the season. From that point on, the cardinals took a turn for the worse. Not only did they flare up, but they also had rumors surrounding Kyler Murray’s future and his eventual contract. With his huge overtime, the Cardinals are now banking on Murray to unleash his Mahomes-like impact on this team.

Here’s everything you need from a Chiefs-Cardinals game betting perspective, from point distribution, moneyline, total over/under and expert insight (odds via FOX Bet):

TIED TOGETHER: Week 1 lines, odds

Kansas City bosses @ Arizona Cardinals (4:25 p.m. ET Sunday, CBS)

Point distribution: Chiefs -6 to win (Chiefs prefer a win by more than 6 points, otherwise Cardinals cover)
money line: Chiefs – 278 favorites to win (bet $10 to win $13.48 total); Cardinals +205 win underdogs (bet $10 to win $20.50 total)
Total score over/under: Both teams scored 53.5 points together

The Chiefs are 26-17 against (ATS) and 33-10 (SU) as street favorites under Andy Reid (since 2013). They are 1-2-1 ATS and 2-2 SU when facing NFC West opponents since 2015, having overturned in three of those games. Andy Reid is 7-6 ATS and 6-7 SU against the Cardinals in his head coaching career.

As of 2019, the Cardinals are 18-9 ATS and 14-12-1 SU as underdogs under Kliff Kingsbury, with the under hit in 14 of those games. As home underdogs, they are 5-4 ATS and 3-5-1 SU over the same period, scoring too many in six of those games.

Patrick Mahomes is 13-12-1 ATS and 21-5 SU as a starter if he’s a career road favorite.

Kyler Murray is 5-4 ATS and 3-5-1 SU as a starter if he has been a career underdog at home.

FOX sports betting analyst Geoff Schwartz:

I don’t make it a habit to bet on fast touchdown road favorites often, so I’ll be playing the Chiefs in a teaser leg. The Chiefs will win this game. For starters, they have the better: coach, quarterback, and offensive and defensive lines. They are a motivated group after their disheartening end to the 2021 season.

Andy Reid was also fabulous at opening weekend games for the Chiefs, winning all but one of those contests in nine seasons with the Chiefs.

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Arizona has many influential players on injury records, and Deandre Hopkins is out for the first six weeks of the season. And while Kyler Murray has gotten off to a quick start every season as the Cardinals’ quarterback — before fading in the second half — he’s struggled without Hopkins. The Chiefs’ defense is younger and faster this season. We’ll see that this weekend.

Are you ready for the NFL season? If so, go to FOX Bet for all your bets.

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