NFL Week 5 odds, picks: Expert predictions, survivor picks, best bets, teasers, and more
Week 5 of the 2022 NFL regular season is packed with storylines. Daniel Jones and co are in London as the Giants look to post an angry win over Aaron Rodgers and the Packers, Patriots rookie quarterback Bailey Zappe gets a chance to smack home fans in his first career start against a holey defense of the Lions and Cooper to inspire Rush and the Cowboys have an opportunity to build on their hot start with a win over reigning Super Bowl Champion Rams in LA
As we do every week, we’ve collected the best tips and gambling content from CBSSports.com and SportsLine and put them all in one place so you can get anti-spread tips from our CBS Sports experts, plus additional content for each game, including plays from top SportsLine -Experts and the SportsLine projection model, our staff’s best bets, survival tips and more. Ready? Let’s jump in!
All NFL odds via Caesars Sportsbook.
What tips can you make with confidence in Week 5? And which Super Bowl contender goes down hard? Visit SportsLine because their incredible model simulates every NFL game 10,000 times and is almost up to date $7,000 for $100 players with top NFL picks since inception.
San Francisco 49ers at the Carolina Panthers
Time: Sunday, 4:05 p.m. ET (CBS), stream on Paramount+ (click here)
Open: 49ers -3.5
Featured Game | Carolina Panthers vs. San Francisco 49ers
“The Carolina Panthers are the least watchable team in the NFL. If watchability rankings don’t matter yet, they should, and the Panthers would be at No. 32 for four weeks. The 49ers should beat Carolina — the only concern is how San Francisco’s offensive line will handle a good Panthers pass rush. Can Jimmy Garoppolo score 21 points? I say yes, which means the Niners will win this one and probably cover with the way the defense is playing right now.
CBS Sports senior analyst and Pick Six podcast host Will Brinson is fading Carolina this week. To read his breakdown of every game this weekend and his best bets, click here.
Philadelphia Eagles at Arizona Cardinals
Time: Sunday, 4:25 p.m. ET (Fox), Stream on fuboTV (Free Trial)
Open: Cardinals -3
Featured Game | Arizona Cardinals vs Philadelphia Eagles
“The Eagles are one of the top teams in the NFL this season, and they’ve covered in each of their last three games after failing to do so in the season opener against the Detroit Lions. I’ve made them the best bet to cover each of the last two weeks, so why stop now? The Eagles look like a complete team to me. Jalen Hurts and offense made the headlines — and I can see why. The Eagles lead the NFL in “big plays” this season with 36. If you’re wondering, “big plays” are rushes of at least 10 yards and passes of at least 20 yards.
The Eagles have led 184 offensive games this season, the most in the NFL, while the Cardinals have led 13 offensive games this season, the worst in the NFL. It was interesting to watch the Cardinals’ defense as they blitz at the highest rate in the NFL (41%) but allow for a 125.8 passer rating with blitz, which ranks 29th in the NFL. hmm
Arizona doesn’t really have home field advantage, as the Cardinals have lost seven straight home games — which is the longest streak of its kind in the NFL. But here’s the most important stat: The cards didn’t cover in all seven of those home games either.”
CBS Sports’ Jordan Dajani is back in Philly this week. Click here to read his Week 5 shortlist here.
Dallas Cowboys at the Los Angeles Rams
Time: Sunday, 4:25 p.m. ET (Fox), Stream on fuboTV (Free Trial)
Open: Aries -5.5
Featured Game | Los Angeles Rams vs. Dallas Cowboys
“As much as I want to ramble on here about the Cowboys being good because of Cooper Rush, I’m not going to because it’s not entirely true. The Cowboys are 3-1 straight because their defense is all smashing: They can stop the run, they can stop the pass, and they’re exceptionally good at embarrassing opposing quarterbacks.
The Cowboys have totaled 15 sacks this season, which is the second-highest total in the NFL. On the other hand, the Rams’ offensive line has suffered throughout the year, making the first four weeks of the season a nightmare for Matthew Stafford.
If you saw what happened to Stafford in Week 1 – he was sacked seven times against the Bills – then you got a taste of what could happen to him this week. If you saw what happened to Matthew Stafford on Monday night – he was sacked seven times against the 49ers – then you got a taste of what could happen to him this week. Stafford has been sacked 16 times this season, which is the second most in the NFL, and based on what I’ve seen of the Cowboys defense, they could double that total.
The problem for the Rams is that they almost never win, win. Stafford is sacked two or more times in a game. In Stafford’s 22 regular-season games with the team, the Rams are 11-1 if he’s sacked once or less, but only 3-6 if he’s sacked multiple times. Basically, the Rams have a hard time winning when Stafford is thrashed.
The other thing about the Cowboys’ defense is that nobody can score against them. The Cowboys haven’t dropped 20 points in any game this year, which is impressive considering they’ve faced quarterbacks like Joe Burrow and Tom Brady before.
Ever since Dak Prescott went down, the Cowboys’ formula for winning games has been pretty simple: Play great defense and pray Cooper Rush doesn’t make mistakes on offense. Well, the prayers clearly worked because Rush had no breaks for four weeks. I have no idea if the Cowboys will stay with Rush for another week or hand offense to Dak Prescott, but I don’t care, I’ll take them no matter what.”
CBS Sports NFL pundit John Breech is riding with “America’s Team” this week. To read his best bets for week 5, click here.
Cincinnati Bengals at Baltimore Ravens
Time: Sunday 8:20 PM ET (NBC), Stream on fuboTV (Free Try)
Open: Ravens -2.5
Featured Game | Baltimore Ravens vs. Cincinnati Bengals
Before you start making Bengals vs. Ravens tips or any other NFL predictions, you need to see which side Mike Tierney is on. Mike Tierney, a veteran sportswriter whose work appears regularly in the New York Times and Los Angeles Times, has covered the NFL for decades, covering seven Super Bowls. In the last four seasons, Mike has reached 232-204 ATS in the NFL. Additionally, Tierney has gone 33-14-1 on his last 48 picks involving the Ravens and returned $1,750. Whoever followed him is way up.
We can tell you he’s leaning under the total, but to see his pick against the spread for this matchup head over to SportsLine.
Las Vegas Raiders vs the Kansas City Chiefs
Time: Monday, 8:15 p.m. ET (ESPN), Stream on fuboTV (free try)
Open: Bosses -6
Featured Game | Kansas City Chiefs vs. Las Vegas Raiders
SportsLine pundit Larry Hartstein is 427-344 all-time on NFL sides (up $3,764 for $100 players), including 394-330 over the spread coming into the 2022 season. Additionally, Hartstein has gone 24-10 on his last 34 picks involving the Chiefs and returned $1,280, so you’ll definitely want to see where he stands Monday night. To see his pick for Chiefs-Raiders, go to SportsLine.