NFL odds Week 2: How to bet Seahawks-49ers, pick

An NFC West rivalry is on the agenda for week 2 of 2022 NFL Season.

The Seattle Seahawks are heading to the Bay to take on the San Francisco 49ers Sunday at 4:05 p.m. ET at Levi’s Stadium.

The Seahawks came off a dismal game Monday night in which they defeated former Seattle quarterback Russell Wilson with his new team, the Denver Broncos. After this resounding victory, a duel with the well-known 49ers will be a good test of the heights this team can reach.

San Francisco lost an ugly game to the Chicago Bears in Week 1, but most discouraging was Trey Lance’s game, who completed 13 of 28 passes for 164 yards and one interception. With Jimmy Garoppolo on the bench after leading the team to the NFC Championship game last season, how long will Lance be on the leash? This competition will be crucial for the future of this team.

Here’s everything you need from a Seahawks-49ers game betting perspective, from point distribution, moneyline, total over/under and expert picks (odds via FOX Bet):

TIED TOGETHER: Does Geno Smith’s play inspire hope?

Seattle Seahawks @ San Francisco 49ers (4:05 p.m., FOX)

Point distribution: san francisco -10 (49ers prefer to win by more than 10 points, else Seahawks cover)
money line: San Francisco -500 favorites to win (bet $10 to win a total of $12); Underdog +333 Underdog win (bet $10 to win $43.30 total)
Total score over/under: Both teams scored 42.5 points together

Seattle Seahawks


San Francisco 49ers


Betting analyst Sam Panayotovich’s pick:

Both teams found themselves in under games on Sunday, but let’s dig a little deeper into the details of what really happened.

San Francisco essentially played in a Chicago swimming pool with monsoon conditions at Soldier Field, and Seattle tucked Denver to the goal line multiple times Monday night to negate any goal flow.

Seattle’s attack is better than the market thinks and I expect Trey Lance to pull back offensively, the right way. A predominantly sunny forecast and temperatures around 70 degrees will help.

SELECT: Both teams scored more than 42.5 points together

Are you ready for the NFL season? If so, go to FOX Bet for all your bets.

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