NFL odds Week 5: How to bet 49ers-Panthers, pick

The San Francisco 49ers (2-2) face the difficult task of flying across the country after playing football Monday night to take on the Carolina Panthers (1-3) on Sunday.

The Panthers lead the all-time streak among NFL teams 13-9.

Here’s everything you need from a betting perspective on the 49ers-Panthers game, from point spread, moneyline, total over/under and expert picks (odds via FOX Bet):

How well Jimmy Garoppolo fits in with 49ers and Kyle Shanahan | THE HERD

How well Jimmy Garoppolo fits in with 49ers and Kyle Shanahan |  THE HERD

The San Francisco 49ers dominated NFC West rivals the Los Angeles Rams with a 24-9 win in the Bay Area.

TIED TOGETHER: Deebo Samuels, defensive shine for the 49ers

49ers @ Panthers (4:05 p.m. ET Sunday, CBS)

Point distribution: 49ers -6.5 (49ers prefer to win by more than 6.5 points, else Panthers cover)
money line: 49ers – 278 favorites to win (bet $10 to win $13.60 total); Panthers +210 Win underdogs (bet $10 to win $31 total)
Total score over/under: Both teams scored 39.5 points together

San Francisco 49ers


Carolina Panther


The 49ers have played 7-2 against the spread (ATS) in their last nine games.

The Under in the Over/Under has scored in the 49ers’ last seven games.

The 49ers are 3-14 ATS in their last 17 games against the Panthers.

The Panthers are 1-10 ATS in their last 11 games.

The Under in the O/U has scored in seven of the Panthers’ last seven games.

The Over in the O/U has scored in 14 of the Panthers’ last 19 games against the 49ers.

Choose over the FOX Sports Betting Analyst Jason McIntyre:

Carolina is possibly the worst team in the NFC who can’t do anything right offensively, having yet to reach 300 yards in a game.

Baker Mayfield is routinely booed for his passes being consistently knocked down at the line of scrimmage, and he is the 33rd QB in the NFL this season (of 33). Ouch. And rookie LT Ikem Ekwonu has struggled and now faces NFL sack leader Nick Bosa (6). Basically, this is going to be a long day for Baker & Co.

That number was 49ers -3 a week ago, but after the game raged on San Francisco Island over the Rams and the Panthers, who were blasted at home by Arizona, it was adjusted to -6.5. A low total (39) and a wide spread is usually a dodge, but this is 49er or pass to me.

SELECT: San Francisco (-6.5 on FOX Bet) wins by more than 6.5 points

Are you ready for the NFL season? If so, go to FOX Bet for all your bets.

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